Stem cell therapy for Multiple Sclerosis
Multiple Sclerosis (MS) is caused by an immune mediated attack targeting components of the myelin sheath. The myelin sheath is known to act as an “insulator” for neurons so that they can communicate properly with each other.
The Scientific Rationale Behind Using Stem Cells To Treat Multiple Sclerosis.
At present there are no FDA-approved treatments that specifically target the abnormal immune responses in MS. Current approaches, such as interferon, copaxone, or immune suppressants all act in a nonspecific manner blocking immune responses against the myelin sheath. While these approaches are useful for reducing the severity of disease, they do not repair the damage to nervous system tissue that has already occurred and therefore they cannot cure multiple sclerosis.
Mesenchymal stem cells (MSCs), have immune regulatory properties which may stop the immune system from attacking the myelin sheath.
Mesenchymal stem cells may also potentially help remyelination (re-generation of the myelin sheath) of the affected neurons.
We published results from our phase 1/2 clinical trial in the March, 2018 edition of the Journal of Translational Medicine. The name of the trial is “Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis“.
This study concluded that “…intravenous infusion of [Umbilical Cord Mesenchymal Stem Cells] UCMSC over several days is safe in subjects with MS. Additionally, UCMSC infusions may hold benefits, since this small study group saw improvement in bladder, bowel, and sexual dysfunction, walking, upper extremity physical function, energy and fatigue, general perspective of a positive health change and improved quality of life, and MRI lesions…”
In addition to our clinical trial findings, we have observed similar types of improvements in multiple sclerosis patients treated at our facilities over the past 13 years.
Dr. Riordan’s book “Stem Cell Therapy: A Rising Tide”
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What are the advantages of treating Multiple Sclerosis with allogeneic umbilical cord tissue-derived stem cells?
No need to collect stem cells from the patient’s hip bone or fat under anesthesia, which can be an unpleasant ordeal.
No need to administer chemotherapy drugs like granulocyte-colony stimulating factor (G-CSF or GCSF) to stimulate the bone marrow to produce granulocytes and stem cells, and release them into the bloodstream.
The stem cells with the best anti-inflammatory activity, immune-modulating capacity, and ability to stimulate regeneration can be screened and selected.
Umbilical cord tissue provides an abundant supply of mesenchymal stem cells.
There is a growing body of evidence showing that umbilical cord tissue-derived (HUCT) mesenchymal stem cells are more robust than mesenchymal stem cells from other sources.
Since HUCT mesenchymal stem cells are immune system-privileged, cell rejection is not an issue, and Human Leukocyte Antigen (HLA) matching is not necessary.
Allogeneic stem cells can be administered multiple times over the course of days in uniform dosages that contain high cell counts.
We use Golden Cells™. Years-long retrospective analysis of patient outcomes has enabled us to identify and select the best cells for use in our patients.
Treatment Protocols
One of our staff physicians will assign a stem cell treatment protocol after you have submitted all requested medical information and received approval. Your recommended protocol may differ from the example given below:
New: Intranasal Mesenchymal Trophic Factors (MTF) Therapy
Note: Note: Includes Hilton hotel room with breakfast, WIFI, transportation from and to the airport with VIP airport gate service and expedited customs clearance upon arrival.
Treatment length: 5 nights
Day 1 Physical examination and blood testing
Day 2-4 3 intravenous infusions + perilymphatic injections of specially selected human umbilical cord tissue-derived allogeneic mesenchymal stem cells (Golden Cells™)
2 Physical therapy sessions
Your questions, answered.
Get answers to frequently asked questions about stem cell therapy, including information on stem cell sources, collection methods, treatment procedures, safety protocols, and more.